The Rise of Mitragyna Speciosa (Kratom) in the USA: A Comprehensive Overview

Mitragyna speciosa, commonly known as Kratom, is a tropical tree native to Southeast Asia, with leaves that contain over 40 alkaloids, notably mitragynine (MG) and 7-hydroxymitragynine (7-HMG). These compounds interact with opioid receptors in the brain, producing stimulatory, analgesic, and anxiolytic effects. While Kratom has been used in Asia for centuries, its popularity in the United States has surged in recent years.

Historical Context and Current Status

Kratom’s use in the U.S. was relatively obscure until the early 2000s, with a significant rise in popularity around 2015. Today, it is readily available in various forms, including loose leaf, powder, capsules, and concentrates, in 46 states (Frontiers in Pharmacology, 2021). The U.S. Food and Drug Administration (FDA) acknowledges the growing interest in Kratom, emphasizing the need for more scientific research to understand its safety issues and potential therapeutic uses (FDA, 2023).

Why is Kratom Gaining Popularity?

  1. Self-Treatment for Health Conditions: Many Americans use Kratom to self-manage chronic pain, fatigue, psychiatric symptoms, and substance use disorders, including opioid withdrawal relief.
  2. Accessibility and Legal Status: Kratom is legal in most U.S. states and is easily accessible online and in stores, making it a convenient option for those seeking its effects.
  3. Opioid Alternative: In regions with high opioid prescription rates and subsequent market changes, Kratom has become a popular alternative, especially in rural areas where treatment for opioid use disorder is less accessible.
  4. Performance Enhancement and Wellness: Beyond self-treatment, Kratom is increasingly sought for its mood-enhancing and energy-boosting properties, aligning with the wellness and nootropic trends.
  5. Media Influence: Discussions about Kratom in popular media, such as The Joe Rogan Experience, have contributed to its rising popularity among younger, educated demographics.

Demographics and Usage Patterns

Kratom users in the U.S. are diverse, but there’s a notable prevalence among young, White, educated males. National surveys indicate varying patterns of use across different regions, with some evidence suggesting higher use in rural areas.

Safety and Regulatory Concerns

The FDA has raised concerns about Kratom’s safety, citing potential opioid-like effects, including sedation, nausea, and the risk of addiction and abuse. However, the agency also recognizes the need for more comprehensive human studies to fully understand Kratom’s abuse potential and therapeutic possibilities.


Mitragyna speciosa, or Kratom, has become a significant substance of interest in the U.S., driven by its perceived benefits in pain and psychiatric symptom management, its role as an opioid alternative, and its growing popularity as a wellness supplement. However, the lack of comprehensive scientific research and regulatory clarity poses challenges and underscores the need for a balanced approach to its use and distribution.